'Shamed' Oprah Winfrey 'Blamed Herself' for Packing on the Pounds Before Using Weight Loss Medications to Shed 50Lbs — And Now She Can't Quit the Jabs

Jan 16, 2026 - 16:30
'Shamed' Oprah Winfrey 'Blamed Herself' for Packing on the Pounds Before Using Weight Loss Medications to Shed 50Lbs — And Now She Can't Quit the Jabs
Oprah dropped about 50 pounds after going on GLP-1 drugs two and a half years ago, but then quickly gained back 20 pounds when she stopped taking them.

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